TNF Receptor I Antibody

Catalog No.

C0375

Size

50 µg

Price

325.00€

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Product details

Applications

IHC ELISA

Source

Rabbit

Reactivity

H, M, R

MW (kDa)

50 kDa

Target Modification

Unmodified/Total

Immunogen

The antiserum was produced against synthesized peptide derived from human TNF Receptor I.

Immunogen Range

381-430

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Specificity

TNF Receptor I Antibody detects endogenous levels of total TNF Receptor I protein.

Gene ID

7132

Swiss-Prot No.

P19438

OMIM No.

142680/191190

Unigene No.

Hs.279594/Hs.713833

NCBI Gene Symbol

TNFRSF1A

Synonyms

CD120a; p55; p60; TBPI; TNF-RI; TNFAR; TNFR1; TNFRSF1A; TNR1A; tumor necrosis factor receptor superfamily member 1A

Storage / Stability

Stable at -20°C for at least 1 year.

Physical Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Concentration

1 mg/ml

Properties

If you buy Antibodies supplied by Assay Biotech they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

French translation

anticorps